Methanol → 2-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

Participants

Reaction Steps

Conc. sulfuric acid (0.42 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) and methanol (20 ml), and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml), and the isolated precipitate was collected by filtration. The precipitate was recrystallized from methanol-water to give 2-[3-(2-cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate (1.53 g).

Provenance & Evidence