Fumaric Acid → 2-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine fumarate

HRID 399872Notes

Reaction equation

HRID 399872 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[C:9]([C:11]1[N:12]([C:16]2[CH:17]=[C:18]([CH:25]=[CH:26][CH:27]=2)[C:19]([N:21]=[C:22]([NH2:24])[NH2:23])=[O:20])[CH:13]=[CH:14][CH:15]=1)#[N:10]>CO>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[C:9]([C:11]1[N:12]([C:16]2[CH:17]=[C:18]([CH:25]=[CH:26][CH:27]=2)[C:19]([N:21]=[C:22]([NH2:23])[NH2:24])=[O:20])[CH:13]=[CH:14][CH:15]=1)#[N:10]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

Product 1

HCID 189452202-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine fumarateYield 70.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of fumaric acid (0.46 g) in methanol (10 ml) was added to a solution of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (1.0 g) in methanol (10 ml) and the whole was stirred for 1 hour at ambient temperature. The isolated precipitate was collected by filtration and the precipitate was recrystallized from methanol-water to give 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine fumarate (1.03 g).

Workup

  1. filtrationThe isolated precipitate was collected by filtration
  2. customthe precipitate was recrystallized from methanol-water

Sources & evidence

ORD record
ord-98a8ec2d00e0446191f19efab8e09b1e
Source dataset
uspto-grants-1998_10
Patent number
US05824691

Reaction notes

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