Acetic Acid → HCID 18945288, compound

Participants

Reaction Steps

2M (Trimethylsilyl)diazomethane in hexane solution (0.84 ml) was added to a mixture of 2-[3-[2-((E)-2-carboxyethenyl)pyrrol-1-yl]benzoyl]guanidine (0.25 g) in tetrahydrofuran (5 ml) and methanol (5 ml) and the mixture was stirred for 25 minutes at the ambient temperature. To the reaction mixture was added acetic acid (2 ml) and stirred for 5 minutes. The mixture of ethyl acetate and water was added to the above mixture and adjusted to pH 8 with 20% aqueous potassium carbonate solution. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was recrystallized from a mixture of ethanol and diisopropyl ether to give 2-[3-[2-((E)-2-methoxycarbonylethenyl)pyrrol-1-yl]benzoyl]guanidine (0.15 g).

Provenance & Evidence