Ethanol → HCID 20211053, compound

Participants

Reaction Steps

A mixture of intermediate (9-a) (7 g), ethanol (160 ml) and sulfuric acid was stirred and refluxed for 1 hour. The reaction mixture was evaporated and the oily residue was taken up in water. After treating with sodium hydroxide, the product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 5 g (63.5%) of ethyl 3,4-dihydro-2H-naphto[1,2-b]pyran-2-carboxylate (interm. 10-a).

Provenance & Evidence