Thiophene → HCID 18694173, compound

Participants

Reaction Steps

A mixture of intermediate 15-b (0.47 mol) in methanol (600 ml) was hydrogenated with palladium on activated carbon, palladium content 10% (5 g) as a catalyst in the presence of a 4% thiophene solution (3 ml). After uptake of H2 (3 equiv), the catalyst was filtered off and the filtrate was evaporated, yielding 130 g (98.3%) of (±)-6-fluoro-3,4-dihydro-2-[[(tetrahydro-2H-pyran-2-yl)oxy]methyl]-2H-1-benzopyran-8-amine (interm. 16-b).

Provenance & Evidence