Hydrochloric Acid → HCID 18694187, compound

Participants

Reaction Steps

A mixture of (±)-N2 -[3-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]amino]propyl]-N4,N4 -dimethyl-2,4-pyrimidinediamine dihydrochloride (0.0067 mol) in methanol (150 ml) was hydrogenated with palladium on activated carbon 10% (2 g) as a catalyst in the presence of a solution of hydrochloric acid in 2-propanol (2 ml). After uptake of hydrogen (2 eq.), the catalyst was filtered off. The filtrate was evaporated and the residue was crystallized twice from methanol. The crystals were filtered off and dried, yielding 0.32 g (13.1%) of (±)-2-[[3-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]amino]propyl]amino]-5,6-dihydro-4(3H)-pyrimidinone dihydrochloride; mp. 273.6° C. (comp. 12-c).

Provenance & Evidence