HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyridin-4-yl)-piperidine-4-carboxylic acid amide hydrochloride → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyridin-4-yl)-piperidine-4-carboxylic acid amide hydrochloride | HCID 67562125 | — |
| Reactant | 2-[1-(3,4,5-Trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate | HCID 86750906 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide | HCID 44319306 | — |
Reaction Steps
Prepare by the method of example 88.6 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (7.5 mmol) and 4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide hydrochloride (5 mmol). Chromatograph on silica gel eluting with 10% methanol/dichloromethane to give the title compound: Rf =0.28 (silica gel, 10% methanol/dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05824690 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-ed9b1c69a6584674a3d6025e20aadb31 |
| Source note | uspto-grants-1998_10 |