1,4-Dioxane hydrochloride → HCID 67540170, compound

HRID 39999Notes

Reaction equation

HRID 39999 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](=[O:39])[N:7]2[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([N:20]([CH2:28][C:29]2[CH:38]=[CH:37][C:32]3[O:33][CH2:34][CH2:35][O:36][C:31]=3[CH:30]=2)C(=O)OC(C)(C)C)[CH2:16][CH2:15]1.Cl.O1CCOCC1>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](=[O:39])[N:7]2[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([NH:20][CH2:28][C:29]2[CH:38]=[CH:37][C:32]3[O:33][CH2:34][CH2:35][O:36][C:31]=3[CH:30]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59398043HCID 59398043, compound

Product 1

HCID 67540170HCID 67540170, compoundYield 129.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 0.28 g of tert-butyl (1-(2-(5-chloro-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)carbamate, 6 mL of 1,4-dioxane and 2 mL of 4 mol/L hydrogen chloride/1,4-dioxane were added, and stirred at room temperature overnight. The resulting solid was filtered to give 0.16 g of 5-chloro-1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)quinolin-2(1H)-one hydrochloride as a white solid.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-6079b4f19ffb4a7193f2a5a8489e7c32
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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