Hydrogen chloride-ethyl acetate → HCID 67538545, compound

HRID 40001Notes

Reaction equation

HRID 40001 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:38])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:24]=[CH:25][C:26]([CH3:37])=[C:27]([NH:29]C(=O)OC(C)(C)C)[CH:28]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:39].C(OCC)(=O)C>>[ClH:39].[NH2:29][C:27]1[CH:28]=[C:23]([CH:24]=[CH:25][C:26]=1[CH3:37])[CH2:22][NH:21][CH:18]1[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][N:10]2[C:11]3[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=3)[N:7]=[CH:8][C:9]2=[O:38])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59397957HCID 59397957, compound

Product 1

HCID 67538545HCID 67538545, compound

Procedure

To 0.28 g of tert-butyl (5-(((1-(2-(7-methoxy-2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)amino)methyl)-2-methylphenyl)carbamate, 30 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, and stirred at room temperature for 41 hours. The solvent was removed under reduced pressure, ethyl acetate was added and the resulting solid was filtered to give 0.26 g of (1-(2-(4-((3-amino-4-methylbenzyl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-6d96f623d3484b55b521edaed1f1830f
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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