4-Phenylpiperidine-4-carboxamide monohydrochloride → HCID 53783400, compound

HRID 400019Notes

Reaction equation

HRID 400019 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([CH2:25][CH2:26]CS([O-])(=O)=O)[CH2:10][CH2:9][N:8]([C:11](=[O:24])[C:12]2[CH:17]=[C:16]([O:18][CH3:19])[C:15]([O:20][CH3:21])=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:7]1.Cl.[C:33]1([C:39]2([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([CH2:25][CH2:26][N:42]2[CH2:41][CH2:40][C:39]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43]2)[CH2:10][CH2:9][N:8]([C:11](=[O:24])[C:12]2[CH:13]=[C:14]([O:22][CH3:23])[C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 30171294-Phenylpiperidine-4-carboxamide monohydrochlorideHCID 86750921HCID 86750921, compound

Product 1

HCID 53783400HCID 53783400, compound

Procedure

Prepare by the method of example 3.3 using 2-[3-(thiophen-2-yl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (8 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (12 mmol). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record
ord-8bb9fc21cf4448bda539a1a541d754ae
Source dataset
uspto-grants-1998_10
Patent number
US05824690

Reaction notes

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