Water → HCID 44319341, compound

Participants

Reaction Steps

Combine 2-[3-(pyridin-3-yl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (0.30 g, 0.65 mmol), 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (0.22 g, 0.9 mmol), and potassium carbonate (0.25 g, 1.8 mmol) in tetrahydrofuran (6 mL)/water (2 mL). Heat to reflux. After 70 hours, evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting sequentially with ethyl acetate, 2% methanol/dichloromethane, 4% methanol/dichloromethane, 6% methanol/dichloromethane, 8% methanol/dichloromethane, and then and 10% methanol/dichloromethane to give the title compound.

Provenance & Evidence