4-Phenylpiperidine-4-carboxamide monohydrochloride → HCID 53736249, compound

HRID 400023Notes

Reaction equation

HRID 400023 reaction equation
[Si]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2([CH2:34][CH2:35]CS([O-])(=O)=O)[CH2:19][CH2:18][N:17]([C:20](=[O:33])[C:21]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=3)[CH2:16]2)=[CH:11][CH:10]=1)(C(C)(C)C)(C)C.Cl.[C:42]1([C:48]2([C:54]([NH2:56])=[O:55])[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2([CH2:34][CH2:35][N:51]3[CH2:50][CH2:49][C:48]([C:42]4[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=4)([C:54]([NH2:56])=[O:55])[CH2:53][CH2:52]3)[CH2:19][CH2:18][N:17]([C:20](=[O:33])[C:21]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=3)[CH2:16]2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 30171294-Phenylpiperidine-4-carboxamide monohydrochlorideHCID 86750924HCID 86750924, compound

Product 1

HCID 53736249HCID 53736249, compound

Procedure

Prepare by the method of example 3.3 using 2-[3-[4-(tert-butyldimethylsilyloxy)-phenyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (8 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (12 mmol). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record
ord-0c7a9b1520fb4994aea8b6557553f6b9
Source dataset
uspto-grants-1998_10
Patent number
US05824690

Reaction notes

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