HRID400027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3017129

4-Phenylpiperidine-4-carboxamide monohydrochloride

C12H17ClN2O

结构：COc1cc(CN2CCC(CCBr)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC

HCID53709262

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC

HCID53969650

未命名化合物

PROCEDURE

实验过程

Prepare according to the method of example 57.8 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide (5 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (7.5 mmol, 1.5 eq.). Chromatograph on silica gel to give the title compound.

WORKUP

后处理

customPrepare

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-01174c4c0980487cba67928b748405aa
来源数据集: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05824690
来源说明: uspto-grants-1998_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:27][CH2:28]Br)[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[C:31]1([C:37]2([C:43]([NH2:45])=[O:44])[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:27][CH2:28][N:40]3[CH2:39][CH2:38][C:37]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)([C:43]([NH2:45])=[O:44])[CH2:42][CH2:41]3)[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]