Ethyl Acetate → HCID 53934277, compound

Participants

Reaction Steps

Combine 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (0.37 g, 0.7 mmol), 4-(methyl-phenyl)-piperidine-4-carboxylic acid amide hydriodide (0.7 mmol) and N,N-diisopropylethylamine (0.36 mL, 2.07 mmol) in acetonitrile (10 mL). Heat to reflux. After 20 hours, evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting sequentially with ethyl acetate and then 10% methanol/ethyl acetate to give the title compound: Rf =0.23 (silica gel, 10% methanol/ethyl acetate).

Provenance & Evidence