4-Phenylpiperidine-4-carboxamide monohydrochloride → HCID 44319355, compound

HRID 400050Notes

Reaction equation

HRID 400050 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([O:32][CH3:33])[C:29]=1[O:30][CH3:31])[C:6]([N:8]1[CH2:12][CH2:11][C:10]([CH2:20][CH2:21]CS([O-])(=O)=O)([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:9]1)=[O:7].Cl.[C:35]1([C:41]2([C:47]([NH2:49])=[O:48])[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([C:10]2([CH2:20][CH2:21][N:44]3[CH2:43][CH2:42][C:41]([C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)([C:47]([NH2:49])=[O:48])[CH2:46][CH2:45]3)[CH2:11][CH2:12][N:8]([C:6](=[O:7])[C:5]3[CH:27]=[C:28]([O:32][CH3:33])[C:29]([O:30][CH3:31])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH2:9]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 30171294-Phenylpiperidine-4-carboxamide monohydrochlorideHCID 86753242HCID 86753242, compound

Product 1

HCID 44319355HCID 44319355, compound

Procedure

Prepare by the method of Example 88.6 using 2-[1-(3,4,5-trimethoxy-benzoyl)-3-(4-chloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride to give the title compound: Rf =0.36 (silica gel, 6% methanol/dichloromethane).

Sources & evidence

ORD record
ord-bfece246862549e5aa101964e97b0a9f
Source dataset
uspto-grants-1998_10
Patent number
US05824690

Reaction notes

Loading…