HCID 67561638, compound → HCID 131720895, compound

HRID 400054Notes

Reaction equation

HRID 400054 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:27][CH2:28]CS([O-])(=O)=O)[CH2:12][CH2:11][N:10]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=3)[CH2:9]2)=[CH:4][CH:3]=1.Cl.[N:35]1([C:41]([NH2:43])=[O:42])[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1.[C:44]1([C:50]2([C:56]([OH:58])=O)[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1>>[N:35]1([C:41]([NH2:43])=[O:42])[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1.[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:27][CH2:28][N:53]3[CH2:52][CH2:51][C:50]([C:44]4[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=4)([C:56]([NH2:35])=[O:58])[CH2:55][CH2:54]3)[CH2:12][CH2:11][N:10]([C:13](=[O:26])[C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=3)[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67561638HCID 67561638, compoundHCID 86753248HCID 86753248, compound

Product 1

HCID 131720895HCID 131720895, compound

Procedure

Prepare by the method of example 88.6 using 2-[3-(4-fluoro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate and 4-phenyl-piperidine-4-carboxylic acid morpholine-amide hydrochloride to give the title compound: Rf =0.57 (silica gel, 10% methanol/dichloromethane).

Sources & evidence

ORD record
ord-9ecbc9a7b04f46daa58ab94fa0f38dee
Source dataset
uspto-grants-1998_10
Patent number
US05824690

Reaction notes

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