HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 67560538, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1-((Tert-butoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid | HCID 736917 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67560538 | HCID 67560538 | — |
Reaction Steps
Combine 1-tert-butoxycarbonyl-4-phenyl-piperidine-4-carboxylic acid (14.5 g, 47.5 mmol) and N-methylpiperazine (12 mL, 108 mmol) in dichloromethane (450 mL), Add HOBt (8.0 g), EDC (11.2 g). After 18 hours, evaporate in vacuo to give a residue, dissolve the residue in ethyl acetate, and extract repeatedly with water. Dry the organic layer over MgSO4, filter, and concentrate in vacuo to give 1-tert-butoxycarbonyl-4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide: Rf =0.33 (6% methanol/dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05824690 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-b552274f5bb14c64bb71a378e38d2ef8 |
| Source note | uspto-grants-1998_10 |