1-Methylpiperazine → 4-(Pyridin-3-yl)-piperidine-4-carboxylic acid 4-methylpiperazine-amide

Participants

Reaction Steps

Prepare by the method of Preparation 16 using 1-benzyl-(4-(pyridin-3-yl)-piperidine-4-carboxylic acid and 4-methylpiperazine to give, after chromatography on silica gel eluting sequentially with 3% methanol/dichloromethane containing 0.5% concentrated aqueous ammonia, 6% methanol/dichloromethane containing 0.5% concentrated aqueous ammonia, 9% methanol/dichloromethane containing 0.5% concentrated aqueous ammonia, and then 12% methanol/dichloromethane containing 0.5% concentrated aqueous ammonia, the title compound.

Provenance & Evidence