3-Cyanopyridine → Nicotinamide

HRID 400094Notes

Reaction equation

HRID 400094 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[OH2:9]>>[C:1]([NH2:2])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1

Participants

3

Reactant 2

HCID 793-CyanopyridineHCID 962Water

Product 1

HCID 936Nicotinamide

Procedure

The strain M33 was grown as in Example 1. A biomass containing M33 cells up to a concentration of 0.5 mg/ml and 3-cyanopyridine up to a concentration of 8% was added into a I00-ml flask containing 40 ml of distilled water (pH 7.6). The flask was incubated at 30° C. under stirring conditions. After 60 minutes, a I0%-nicotinamide solution was obtained. Nicotinic acid and 3-cyanopyridine were not present in the reaction mixture.

Workup

  1. additionwas added into a I00-ml flask
  2. customwas incubated at 30° C. under stirring conditions

Sources & evidence

ORD record
ord-f9992b8551df4c01b222d5ff42d9bb6a
Source dataset
uspto-grants-1998_10
Patent number
US05827699

Reaction notes

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