Hydrochloric Acid → HCID 131720905, compound

Participants

Reaction Steps

The above ester (1.23 g, 0.003 mol) was dissolved in ethanol (15 ml). 2 N Sodium hydroxide (4.0 ml) was added and the mixture was stirred for 1 h at room temperature. The solution was made acidic (pH 1) by addition of excess 1 N hydrochloric acid and concentrated in vacuo to remove ethanol. The remainder was extracted with diethyl ether (50 ml) and redissolved in dichloromethane (50 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo. Crystallisation of the remainder from acetone (20 ml) afforded 0.78 g (62%) of the title compound as a crystalline powder.

Provenance & Evidence