HCID 178468432, compound → HCID 178470071, compound

HRID 400111Notes

Reaction equation

HRID 400111 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:16]2[CH2:15][CH2:14][N:13]([CH2:17][C:18]3C=CC=CC=3)[CH2:12][CH2:11][C:10]=2[CH:9]=[N+:8]([O-])[C:7]=1[OH:25])=[O:5])[CH3:2]>C(O)C.[Ni]>[CH2:1]([O:3][C:4]([C:6]1[C:16]2[CH2:15][CH2:14][N:13]([CH2:17][CH3:18])[CH2:12][CH2:11][C:10]=2[CH:9]=[N:8][C:7]=1[OH:25])=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 178468432HCID 178468432, compound

Product 1

HCID 178470071HCID 178470071, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

Prepared from 4-ethoxycarbonyl-3-hydroxy-7-benzyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine 2-oxide by hydrogenation in ethanol at 130° C. in the presence of Raney nickel.

Sources & evidence

ORD record
ord-288df4fe5f8b4695a4333643bfd3f720
Source dataset
uspto-grants-1998_10
Patent number
US05827849

Reaction notes

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