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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 400114Generated: October 25, 2026

1-Benzylazepan-4-one hydrochloride → 1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochloride

https://huagongshe.com/reaction/400114

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Benzylazepan-4-one hydrochlorideHCID 13072029—
ReactantDMF Phosphorus oxychlorideHCID 13765457—
SolventDichloromethaneHCID 6344—
Product1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochlorideHCID 18943541—

Reaction Steps

Prepared from 1-benzylhexahydro-4-azepinone hydrochloride by reaction with dimethylformamide/phosphorus oxychloride in methylene chloride at 20°-35° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05827849
Source datasetuspto-grants-1998_10
ORD IDord-ade65bfcd2d1453199638053f587eedf
Source noteuspto-grants-1998_10