Hydrogen chloride-ethyl acetate → 7-methoxy-1-(2-(4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethyl)amino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride

HRID 40012Notes

Reaction equation

HRID 40012 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:34])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]4[C:26]([CH2:27][CH2:28][C:29](=[O:33])[NH:30]4)=[CH:25][CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:35].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:35].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:34])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:16][CH2:17][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]4[C:26]([CH2:27][CH2:28][C:29](=[O:33])[NH:30]4)=[CH:25][CH:24]=3)[CH2:19][CH2:20]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59397910HCID 59397910, compound

Product 1

HCID 675387447-methoxy-1-(2-(4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethyl)amino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To 5 mL of a chloroform solution containing 169 mg of 7-methoxy-1-(2-(4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethyl)amino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate and 5 mL of chloroform were added, and stirred at room temperature. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 166 mg of 7-methoxy-1-(2-(4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethyl)amino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale brown powder.

Workup

  1. additionwere added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-edd1990de24c426d86ff3be197810108
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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