Pravastatin Diol Lactone Di-(tert-butyldimethylsilyl) Ether → HCID 53787878, compound

Participants

Reaction Steps

A procedure similar to that described in Example 4, above, was followed, but using 2.0 g (3.6 mmol) of (4R,6R)-6-{2-[(1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-6-t-butyldimethylsilyloxy-8-hydroxy-2-methyl-1-naphthyl]ethyl}tetrahydro-4-t-butyldimethylsilyloxy-2H-pyran-2-one [prepared as described in Example B, above] and 1.92 g (10.9 mmol) of 2-methyl-2-propylvaleryl chloride, to provide 1.05 g of the title compound.

Provenance & Evidence