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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 400147Generated: October 29, 2026

HCID 5325505, compound → HCID 67640408, compound

https://huagongshe.com/reaction/400147

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 5325505HCID 5325505—
ReactantPravastatin Diol Lactone Di-(tert-butyldimethylsilyl) EtherHCID 14600906—
ProductHCID 67640408HCID 6764040816.2%

Reaction Steps

A procedure similar to that described in Example 4, above, was followed, but using 1.0 g (1.8 mmol) of (4R,6R)-6-{2-[(1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-6-t-butyldimethylsilyloxy-8-hydroxy-2-methyl-1-naphthyl]ethyl}tetrahydro-4-t-butyldimethylsilyloxy-2H-pyran-2-one [prepared as described in Example B, above] and 888 mg (5.5 mmol) of 2-isopropyl-3-methylbutyryl chloride, to provide 198 mg of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05827855
Source datasetuspto-grants-1998_10
ORD IDord-97553309f865412fa01b7cb9c86879ad
Source noteuspto-grants-1998_10