Pravastatin Diol Lactone Di-(tert-butyldimethylsilyl) Ether → HCID 22856158, compound

Participants

Reaction Steps

A procedure similar to that described in Example 6, above, was followed, but using 1.10 g (2.0 mmol) of (4R,6R)-6-{2-[(1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-6-t-butyldimethylsilyloxy-8-hydroxy-2-methyl-1-naphthyl]ethyl}tetrahydro-4-t-butyldimethylsilyloxy-2H-pyran-2-one [prepared as described in Example B, above] and 1.63 g (10.0 mmol) of 2,2-dimethylhexanoyl chloride, to provide 1.22 g of the title compound.

Provenance & Evidence