Hydrogen chloride-ethyl acetate → HCID 67539282, compound

HRID 40020Notes

Reaction equation

HRID 40020 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:35])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]([O:33][CH3:34])[C:26]4[O:27][CH2:28][CH2:29][O:30][C:25]=4[CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:36].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:36].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:35])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]([O:33][CH3:34])[C:26]4[O:27][CH2:28][CH2:29][O:30][C:25]=4[CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983727-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

Product 1

HCID 67539282HCID 67539282, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To 10 mL of a chloroform solution containing 478 mg of 7-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate and 5 mL of chloroform were added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 429 mg of 7-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a dark brown powder.

Workup

  1. additionwere added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-1292a5c68c664ecc89730649bc39f57d
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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