1,4-Dioxane → HCID 21841477, compound

Participants

Reaction Steps

A mixture of 3 g of the product of Stage A, 1.66 g of boronic acid (Preparation 5), 3.5 g of monohydrated potassium phosphate, 1.32 g of potassium bromide and 300 mg of Pd(PPh3)4 (palladium tetrakis) in 50 ml of dioxane was refluxed for 12 hours. After pouring the reaction medium into a water-ice mixture, and carrying out extraction with ethyl acetate, the organic phase was dried, filtered and evaporated under reduced pressure. The crude product was purified by chromatography, eluting with a cyclohexane/ethyl acetate mixture (85/15) to obtain 1.95 g of the expected product with a Rf=0.05 (cyclohexane/ethyl acetate 85/15).

Provenance & Evidence