反应详情

To 3 mL of a chloroform solution containing 171 mg of 1-(2-(4-((2,2-difluorobenzo[1,3]dioxol-5-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 0.5 mL of 4 mol/L hydrogen chloride/ethyl acetate and 3 mL of chloroform were added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added and the resulting solid was filtered to give 150 mg of 1-(2-(4-((2,2-difluoro-benzo[1,3]dioxol-5-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a pale brown powder.

1. additionwere added
2. customThe solvent was removed under reduced pressure, ethyl acetate
3. additionwas added
4. filtrationthe resulting solid was filtered