Benzoyl chloride → HCID 18944025, compound

Participants

Reaction Steps

To a solution of the compound obtained in example 44 (0.5 g, 1.13 mmol) in pyridine (10.8 mL) was added benzoyl chloride (0.13 mL) and the reaction mixture was stirred at room temperature under an argon atmosphere for 12 h. Then, saturated aqueous KH2PO4 (33 mL) was added and it was extracted with EtOAc. The organic phase was unwashed with 1N HCl, dried and concentrated to a crude product. This was chromatographed on silica gel (hexane-EtOAc, 1:1) to afford the title compound as a foam (0.64 g, 100%).

Provenance & Evidence