Water → HCID 294205, compound

Decanoic acid (4 g, 23.2 mmol) was dissolved in an anhydrous dichloromethane solution (80 mL), and 1,1-carbonyldiimidazole (4.5 g, 27.9 mmol) was then added to the solution, followed by stirring for 1.5 hours. Subsequently, N,O-dimethylhydroxyamine hydrochloride (2.7 g, 27.9 mmol) was added to the reaction solution, and the obtained mixture was further stirred for 3 hours. After addition of distilled water, the reaction solution was extracted with dichloromethane two times. Anhydrous magnesium sulfate was added to the organic layer to dry it, and the resultant was filtrated and was then concentrated. The obtained residue was purified using column chromatography (hexane:ethyl acetate=8:1), so as to obtain N-methoxy-N-methyldecanamide (4.8 g, 97%) as an amide body in the form of a colorless transparent liquid.

1. additionwas then added to the solution
2. stirringthe obtained mixture was further stirred for 3 hours
3. extractionthe reaction solution was extracted with dichloromethane two times
4. additionAnhydrous magnesium sulfate was added to the organic layer
5. customto dry it
6. filtrationthe resultant was filtrated
7. concentrationwas then concentrated
8. customThe obtained residue was purified

ORD record

ord-ca611b5c5ba04339a7d021a1bbd71ce8

Source dataset

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08741871B2