HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl iodide → 1-Benzyl-6-butoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl iodide | HCID 10962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Benzyl-N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1H-indole-3-carboxamide | HCID 25160740 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Benzyl-6-butoxy-N-(3,4-difluorobenzyl)-2-isopropyl-1H-indole-3-carboxamide | HCID 25059486 | — |
Reaction Steps
Following General Procedure A, 1-benzyl-N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1H-indole-3-carboxamide (Compound 8, 10.7 mg, 0.025 mmol) in DMF (1.0 ml) was reacted with K2CO3 (10.0 mg, 0.074 mmol) and 1-iodobutane (14.0 μl, 0.12 mmol) to yield the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524917B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-6630d267d443451cb8ba923bdeeca4eb |
| Source note | uspto-grants-2013_09 |