HuagongsheHuagongshe Chemistry Print Report · For research reference only
Barbituric Acid → 2,4,6-Trioxohexahydropyrimidine-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Barbituric Acid | HCID 6211 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Product | 2,4,6-Trioxohexahydropyrimidine-5-carbaldehyde | HCID 351701 | — |
Reaction Steps
9.03 ml of phosphoryl chloride are added dropwise to 2 ml of dry DMF with ice-cooling. 1.5 g of barbituric acid are subsequently added, and the mixture is stirred at 100° for 4 h. The mixture is cooled, poured into ice-water, the precipitate is separated off, rinsed with water and dried at 45°, giving 2.5 g of “1”.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741896B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-10417475da6d40dbb7657d2781a3f4df |
| Source note | uspto-grants-2014_06 |