HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 18327906, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Tert-butyl 4-hydroxy-4-(pyrimidin-2-yl)piperidine-1-carboxylate | HCID 23302196 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 18327906 | HCID 18327906 | 81.6% |
Reaction Steps
110 mg 4-hydroxy-4-pyrimidin-2-yl-piperidine-1-carboxylic acid tert-butyl ester was dissolved in 2.5 mL pyridine and 0.18 ml phosphoroxychloride was added. The reaction was stirred one day at RT. The reaction was decomposed with water and extracted with DCM. The organic layer was dried and the solvent was removed to give 84 mg of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741892B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-cff421de76354388805b8cdfcd739411 |
| Source note | uspto-grants-2014_06 |