HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(6-Methoxy-pyrimidin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester → 4-Methoxy-6-piperidin-4-yl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(6-Methoxy-pyrimidin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686031 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Methoxy-6-piperidin-4-yl-pyrimidine | HCID 82656660 | 31.4% |
Reaction Steps
1.16 g 4-(6-Methoxy-pyrimidin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester were stirred in 2 mL 4 mol/L HCl solution in dioxane for 40 min. The mixture was diluted with dioxane and basified with sodiumcarbonate. The suspension was filtered and the filtrate was concentrated to give 0.24 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741892B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-c1ed6236f76444be968135cc09aec311 |
| Source note | uspto-grants-2014_06 |