反应详情

4.55 g thiourea was added to 15.2 g 3-Bromo-piperidin-4-one hydrobromide in 152 mL ethanol and refluxed for 20 h. The reaction was cooled and the solid was filtered, washed with ethanol and dried to give 15.8 g of the desired product.

1. temperaturerefluxed for 20 h
2. temperatureThe reaction was cooled
3. filtrationthe solid was filtered
4. washwashed with ethanol
5. customdried