Thiourea → 4,5,6,7-Tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine dihydrobromide

HRID 400426Notes

Reaction equation

HRID 400426 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[BrH:5].[Br:6][CH:7]1[C:12](=O)[CH2:11][CH2:10][NH:9][CH2:8]1>C(O)C>[BrH:6].[BrH:5].[N:1]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[S:3][C:2]=1[NH2:4]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 141969683-Bromopiperidin-4-one hydrobromide

Product 1

HCID 467360514,5,6,7-Tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine dihydrobromideYield 84.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.55 g thiourea was added to 15.2 g 3-Bromo-piperidin-4-one hydrobromide in 152 mL ethanol and refluxed for 20 h. The reaction was cooled and the solid was filtered, washed with ethanol and dried to give 15.8 g of the desired product.

Workup

  1. temperaturerefluxed for 20 h
  2. temperatureThe reaction was cooled
  3. filtrationthe solid was filtered
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-68a607483a764d999179b43dd512532d
Source dataset
uspto-grants-2014_06
Patent number
US08741892B2

Reaction notes

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