反应详情

95 mg acetyl chloride was added to 312 mg 2-Amino-4,5,7,8-tetrahydro-thiazolo (4,5-d) azepine-6-carboxylic acid tert-butyl ester in 5 mL pyridine at 15° C. The reaction was stirred 3 h at RT. The reaction was diluted with dichlormethane and 1 mL water was added. The solution was filtered over 40 mL Alox and 100 mL Extrelut and evaporated to give 127 mg desired product. (M+H)+: 312

1. additionwas added
2. filtrationThe solution was filtered over 40 mL Alox and 100 mL Extrelut
3. customevaporated