HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 4-(5-Isopropyl-(1,3,4)oxadiazol-2-yl)-4-methyl-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 4-(5-Isopropyl-(1,3,4)oxadiazol-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686036 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(5-Isopropyl-(1,3,4)oxadiazol-2-yl)-4-methyl-piperidine | HCID 86686037 | 117.5% |
Reaction Steps
150 mL saturated dioxane-HCl was added to 19 g 4-(5-isopropyl-(1,3,4)oxadiazol-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester in 100 mL dioxane at 0° C. The mixture was stirred at RT for 2 h. The precipitate was filtered and washed with ethyl acetate to give 15.1 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741892B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-45a3b2903e094e45b473169544bb18b4 |
| Source note | uspto-grants-2014_06 |