1-Chloroethyl chloroformate → HCID 86686045, compound

Participants

Reaction Steps

20 g 1-chloroethyl chloroformate was added to 24 g 1-benzyl-4-(5-methyl-oxazol-2-yl)-1,2,3,6-tetrahydro-pyridine in 200 mL anhydrous dichlormethane at 0° C. under nitrogen atmosphere. After 2 h, the solution was concentrated and 200 mL anhydrous methanol was added. The mixture was heated at reflux for 4 h and concentrated. The resulting crude product was re-crystallized from dichlormethane to give 16 g of the desired product.

Provenance & Evidence