HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 400445Generated: October 29, 2026
Water → tert-Butyl 4-cyanopiperazine-1-carboxylate
https://huagongshe.com/reaction/400445
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tert-Butyl 4-cyanopiperazine-1-carboxylate | HCID 14068968 | 99.9% |
Reaction Steps
3.76 g bromcyane was added to 6 g piperazine-1-carboxylic acid tert-butyl ester and 6.3 mL DIPEA in 30 mL dichlormethane at 0° C. The reaction was stirred 1.5 h at 0° C. Water and dichlormethane was added and the layers were separated. The organic layer was washed with brine and water and evaporated to give 6.8 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08741892B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-2afb461737ab4519b1c24934a05f4261 |
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| Source note | uspto-grants-2014_06 |
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