HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 400448Generated: October 29, 2026
Water → 4-(4-Methyl-oxazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/400448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydroxyacetone | HCID 8299 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | tert-Butyl 4-cyanopiperazine-1-carboxylate | HCID 14068968 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4-Methyl-oxazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 86686048 | — |
Reaction Steps
17 mL 2 mol/L aqueous sodium hydroxide solution was dropped to 6.7 g 4-cyano-piperazine-1-carboxylic acid tert-butyl ester and 2.5 mL 1-hydroxy-propan-2-one in 10 mL THF. The reaction was stirred 12 h at RT and over night at 75° C. The reaction was cooled, water was added and the mixture was diluted with diethylether. The precipitate was filtered to give 1.32 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08741892B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-e3c0547f944e48b6a9cc2ca949ed6265 |
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| Source note | uspto-grants-2014_06 |
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