HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Benzyl 3-acetamido-4-hydroxypyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Benzyl 3-amino-4-hydroxypyrrolidine-1-carboxylate | HCID 17917965 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl 3-acetamido-4-hydroxypyrrolidine-1-carboxylate | HCID 86686049 | 90.9% |
Reaction Steps
3.24 g acetic anhydride was added to 7.1 g benzyl 3-amino-4-hydroxypyrrolidine-1-carboxylate in 100 mL dichlormethane at 0-5° C. The mixture was stirred 2 h at RT, 100 mL diethylether was added and the mixture was stirred for 15 min. The precipitate was filtered to give 7.6 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741892B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-5390c99a64d24fc19fc814ee9fa96953 |
| Source note | uspto-grants-2014_06 |