Hydrochloric Acid → 2-Methyl-2,5,6,7,8,9-hexahydro-1,2,7-triaza-benzocyclohepten-3-one hydrochloride

Participants

Reaction Steps

40 mL dioxane solution of hydrogen chloride was added to 5.5 g 3-phenyl-5,6,8,9-tetrahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester in 40 mL dioxane at 5° C. The reaction was stirred over night. The solvent was removed and co-evaporated with ethyl acetate to yield 3.7 g of the desired product. (M+H)+: 180, Rt: 7.84 min (method AE)

Provenance & Evidence