HCID 46221901, compound → HCID 46221905, compound

Participants

Reaction Steps

The compound of Example 1 (9 mg, 0.02 mmol) and palladium hydroxide on carbon (20 wt %, 15 mg) in MeOH (ca 10 mL) were stirred under a hydrogen atmosphere (balloon). After stirring for several hours the solution was filtered through celite and concentrated. The residue was purified by preparative TLC using 5% MeOH/DCM as the eluent to give the indicated compound. 1H NMR (500 MHz, DMSO-d6): δ 11.08 (s, 1H); 8.82 (d, J=8.5 Hz, 1H); 7.89 (d, J=8.0 Hz, 1H); 7.53 (t, J=7.8 Hz, 1H); 7.31 (t, J=7.5 Hz, 1H); 6.94 (s, 2H); 3.28-3.21 (m, 2H); 2.89-2.77 (m, 2H); 1.35 (s, 6H). LC4 rt=3.42 min, m/z=391 (M+H).

Provenance & Evidence