反应详情

To a solution of ethyl-4-iodobenzoate ( 10.0 g, 36.2 mmol) in H2SO4 (20 ml) at 0° C. was added dropwise HNO3 ( 4.7 ml, 72.4 mmol). Reaction was stirred at room temperature for 1 h, cooled to 0° C., quenched with ice, diluted with EtOAc, washed with H2O, brine, dried over Na2SO4, concentrated in vacuo to yield the crude title compound as a yellow solid.

1. customReaction
2. temperaturecooled to 0° C.
3. customquenched with ice
4. additiondiluted with EtOAc
5. washwashed with H2O, brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo