反应详情

2-bromo-3-methylpyridine (25.0 mL, 213 mmol) was added to a solution of potassium permanganate (87.7 g, 555 mmol) in 800 mL of water and the mixture was stirred under reflux. After 5 hours, 600 mL of water was distilled off and the remaining suspension was filtered. The residue was washed with two 50 mL portions of hot water and the combined filtrates were acidified with concentrated HCl. The white precipitate was filtered and dried in a vacuum oven to give 26.8 g of 2-bromonicotinic acid (62% yield).

1. temperatureunder reflux
2. distillation600 mL of water was distilled off
3. filtrationthe remaining suspension was filtered
4. washThe residue was washed with two 50 mL portions of hot water
5. filtrationThe white precipitate was filtered
6. customdried in a vacuum oven