HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridazine → 3-Bromopyridazin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridazine | HCID 298492 | — |
| Reactant | 3-Bromo-2,6-dimethyl-4-pyridinamine | HCID 10512262 | — |
| Product | 3-Bromopyridazin-4-amine | HCID 53485356 | 15% |
| Product | 5-Bromopyridazin-4-amine | HCID 60026667 | 5% |
Reaction Steps
Bromination of pyridazin-4-ylamine was performed in the same manner as for the preparation of 4-amino-3-bromo-2,6-dimethylpyridine. Chromatography on SiO2 (20% ethyl acetate in hexanes to 100% ethyl acetate, gradient, followed by 2% methanol in ethyl acetate) yielded 4-amino-3-bromopyridazine (first eluting: 15% yield) and 4-amino-5-bromopyridazine (second eluting: 5% yield) as tan solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741897B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-78679f8e8f5a425f8e797a1019a0471e |
| Source note | uspto-grants-2014_06 |