Tetrahydrofuran → HCID 60026398, compound

Participants

Reaction Steps

A solution of 1,1,1-trifluoro-4-(5-methanesulfonyl-2,3-dihydrobenzofuran-7-yl)-4-methylpentan-2-one (5.4 g, 15.4 mmol) in a mixture of 10 mL of anhydrous diethyl ether and 10 mL of anhydrous THF was treated with the organoaluminum reagent at −78° C. After 1 hour at −78° C. and 1 hour at room temperature, the reaction mixture was quenched with saturated ammonium chloride solution and diluted with water. The aqueous layer was extracted with three 100 mL portions of ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to give 6.3 g of the title product as a solid, which was used without further purification (quantitative yield).

Provenance & Evidence