Ethanol → HCID 60026335, compound

Participants

Reaction Steps

A mixture of 4-(3-[1,3]dioxan-2-ylphenyl)-1,1,1-trifluoro-4-methyl-2-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-ol (160 mg, 0.36 mmol), 2 mL of ethanol, 1 mL of water, and pyridinium p-toluenesulfonic acid (200 mg, 0.8 mmol) was stirred at room temperature for 14 hours and then concentrated in vacuo to remove ethanol. The residue was diluted with ethyl acetate and water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with aqueous saturated sodium bicarbonate solution and brine, and dried over sodium sulfate. Removal of the solvent in vacuo afforded 134 mg (95% yield) of the title compound.

Provenance & Evidence