Potassium Hydroxide → HCID 60026523, compound

Participants

Reaction Steps

A solution of 2-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-indole-4-carboxylic acid ethyl ester (220 mg, 0.470 mmol) in 10 mL of methanol was treated with a solution of potassium hydroxide (85 mg, 1.5 mmol) in 3 mL of water. The resulting mixture was stirred at room temperature for 4 hours, refluxed for 6 hours, cooled to room temperature, and concentrated in vacuo. The residue was treated with cold 1 N sulfuric acid and extracted with three 30 mL portions of dichloromethane. The combined organic layers were washed with water, dried over sodium sulfate, filtered, and concentrated in vacuo to give 190 mg of the title product as a light cream solid (89% yield).

Provenance & Evidence